Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 325662..326248 Replicon chromosome
Accession NZ_CP103550
Organism Klebsiella pneumoniae strain 2791

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag M5T34_RS01515 Protein ID WP_002920800.1
Coordinates 325880..326248 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag M5T34_RS01510 Protein ID WP_004174006.1
Coordinates 325662..325883 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T34_RS01490 (321819) 321819..322745 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
M5T34_RS01495 (322742) 322742..324019 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
M5T34_RS01500 (324016) 324016..324783 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
M5T34_RS01505 (324785) 324785..325498 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
M5T34_RS01510 (325662) 325662..325883 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M5T34_RS01515 (325880) 325880..326248 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
M5T34_RS01520 (326521) 326521..327837 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
M5T34_RS01525 (327944) 327944..328831 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
M5T34_RS01530 (328828) 328828..329673 + 846 WP_032434559.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
M5T34_RS01535 (329675) 329675..330745 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 322742..331482 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T255450 WP_002920800.1 NZ_CP103550:325880-326248 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT255450 WP_004174006.1 NZ_CP103550:325662-325883 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References