Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4568503..4569105 Replicon chromosome
Accession NZ_CP103544
Organism Escherichia coli strain 3036

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag M5S54_RS21945 Protein ID WP_000897305.1
Coordinates 4568794..4569105 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5S54_RS21940 Protein ID WP_000356397.1
Coordinates 4568503..4568793 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S54_RS21915 (4564428) 4564428..4565330 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
M5S54_RS21920 (4565327) 4565327..4565962 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
M5S54_RS21925 (4565959) 4565959..4566888 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
M5S54_RS21930 (4567218) 4567218..4567460 - 243 WP_001087409.1 protein YiiF -
M5S54_RS21935 (4567680) 4567680..4567898 - 219 WP_001315930.1 CopG family transcriptional regulator -
M5S54_RS21940 (4568503) 4568503..4568793 - 291 WP_000356397.1 NadS family protein Antitoxin
M5S54_RS21945 (4568794) 4568794..4569105 - 312 WP_000897305.1 hypothetical protein Toxin
M5S54_RS21950 (4569334) 4569334..4570242 + 909 WP_259418694.1 alpha/beta hydrolase -
M5S54_RS21955 (4570306) 4570306..4571247 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M5S54_RS21960 (4571292) 4571292..4571729 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
M5S54_RS21965 (4571726) 4571726..4572598 - 873 WP_000920762.1 virulence factor BrkB family protein -
M5S54_RS21970 (4572592) 4572592..4573191 - 600 WP_001295269.1 glucose-1-phosphatase -
M5S54_RS21975 (4573290) 4573290..4574075 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T255417 WP_000897305.1 NZ_CP103544:c4569105-4568794 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT255417 WP_000356397.1 NZ_CP103544:c4568793-4568503 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References