255389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2406288..2406926 Replicon chromosome
Accession NZ_CP103540
Organism Escherichia coli strain 5264

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag M5S66_RS11580 Protein ID WP_001447010.1
Coordinates 2406750..2406926 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5S66_RS11575 Protein ID WP_001270286.1
Coordinates 2406288..2406704 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S66_RS11555 (2401440) 2401440..2402381 - 942 WP_001251304.1 ABC transporter permease -
M5S66_RS11560 (2402382) 2402382..2403395 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M5S66_RS11565 (2403413) 2403413..2404558 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M5S66_RS11570 (2404803) 2404803..2406209 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M5S66_RS11575 (2406288) 2406288..2406704 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5S66_RS11580 (2406750) 2406750..2406926 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5S66_RS11585 (2407148) 2407148..2407378 + 231 WP_000494244.1 YncJ family protein -
M5S66_RS11590 (2407470) 2407470..2409431 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5S66_RS11595 (2409504) 2409504..2410040 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M5S66_RS11600 (2410132) 2410132..2411307 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2411347..2412495 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T255389 WP_001447010.1 NZ_CP103540:c2406926-2406750 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT255389 WP_001270286.1 NZ_CP103540:c2406704-2406288 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References