Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1809981..1810483 Replicon chromosome
Accession NZ_CP103540
Organism Escherichia coli strain 5264

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag M5S66_RS08635 Protein ID WP_000767832.1
Coordinates 1810229..1810483 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M5S66_RS08630 Protein ID WP_001259255.1
Coordinates 1809981..1810232 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S66_RS08605 (1805159) 1805159..1806226 - 1068 WP_000080064.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M5S66_RS08610 (1806226) 1806226..1807296 - 1071 WP_094336856.1 histidinol-phosphate transaminase -
M5S66_RS08615 (1807293) 1807293..1808597 - 1305 WP_024198577.1 histidinol dehydrogenase -
M5S66_RS08620 (1808603) 1808603..1809502 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M5S66_RS08625 (1809648) 1809648..1809698 - 51 WP_001364200.1 his operon leader peptide -
M5S66_RS08630 (1809981) 1809981..1810232 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M5S66_RS08635 (1810229) 1810229..1810483 + 255 WP_000767832.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M5S66_RS08640 (1810566) 1810566..1811390 + 825 WP_000754737.1 SDR family oxidoreductase -
M5S66_RS08645 (1811436) 1811436..1812365 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
M5S66_RS08650 (1812579) 1812579..1812641 + 63 WP_097433929.1 membrane protein YoeI -
M5S66_RS08655 (1812631) 1812631..1813989 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10232.66 Da        Isoelectric Point: 8.0280

>T255383 WP_000767832.1 NZ_CP103540:1810229-1810483 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHYLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT255383 WP_001259255.1 NZ_CP103540:1809981-1810232 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References