Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2245728..2246596 | Replicon | chromosome |
| Accession | NC_015848 | ||
| Organism | Mycobacterium canettii CIPT 140010059 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | MCAN_RS10275 | Protein ID | WP_162138899.1 |
| Coordinates | 2245728..2246105 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | MCAN_RS10280 | Protein ID | WP_003409886.1 |
| Coordinates | 2246147..2246596 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MCAN_RS10230 | 2241515..2241967 | - | 453 | WP_003899095.1 | lipoprotein | - |
| MCAN_RS10235 | 2242031..2242432 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| MCAN_RS10240 | 2242425..2242607 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| MCAN_RS10245 | 2242721..2243071 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| MCAN_RS10250 | 2243082..2243984 | - | 903 | WP_080603716.1 | hypothetical protein | - |
| MCAN_RS21435 | 2244005..2244197 | - | 193 | Protein_2013 | hypothetical protein | - |
| MCAN_RS10255 | 2244198..2244494 | - | 297 | WP_014001026.1 | hypothetical protein | - |
| MCAN_RS10260 | 2244735..2244950 | + | 216 | WP_003409878.1 | antitoxin | - |
| MCAN_RS10265 | 2244947..2245258 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| MCAN_RS22805 | 2245232..2245753 | - | 522 | WP_014001027.1 | hypothetical protein | - |
| MCAN_RS10275 | 2245728..2246105 | + | 378 | WP_162138899.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| MCAN_RS10280 | 2246147..2246596 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| MCAN_RS10285 | 2246593..2247138 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| MCAN_RS10290 | 2247027..2247641 | - | 615 | WP_014001029.1 | hypothetical protein | - |
| MCAN_RS10295 | 2247691..2247987 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MCAN_RS10300 | 2247984..2248235 | - | 252 | WP_014001030.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| MCAN_RS10305 | 2248222..2248713 | + | 492 | WP_014001031.1 | hypothetical protein | - |
| MCAN_RS10310 | 2248873..2249280 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| MCAN_RS10315 | 2249284..2249556 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MCAN_RS10320 | 2249589..2250809 | - | 1221 | WP_014001032.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14464.85 Da Isoelectric Point: 11.0198
>T25531 WP_162138899.1 NC_015848:2245728-2246105 [Mycobacterium canettii CIPT 140010059]
VPPPDPRAIGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPRAIGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T25531 NC_015848:2245728-2246105 [Mycobacterium canettii CIPT 140010059]
GTGCCGCCCCCTGATCCACGCGCCATAGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
GTGCCGCCCCCTGATCCACGCGCCATAGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT25531 WP_003409886.1 NC_015848:2246147-2246596 [Mycobacterium canettii CIPT 140010059]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT25531 NC_015848:2246147-2246596 [Mycobacterium canettii CIPT 140010059]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|