Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1112628..1113355 | Replicon | chromosome |
| Accession | NZ_CP103521 | ||
| Organism | Escherichia coli strain 2779 - blood draw same patient as MB9267 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A829L2T9 |
| Locus tag | M5S63_RS05335 | Protein ID | WP_001521139.1 |
| Coordinates | 1112628..1112939 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | M5S63_RS05340 | Protein ID | WP_000126294.1 |
| Coordinates | 1112936..1113355 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M5S63_RS05310 (1108563) | 1108563..1110272 | + | 1710 | WP_001521140.1 | formate hydrogenlyase subunit HycE | - |
| M5S63_RS05315 (1110282) | 1110282..1110824 | + | 543 | WP_000493785.1 | formate hydrogenlyase subunit HycF | - |
| M5S63_RS05320 (1110824) | 1110824..1111591 | + | 768 | WP_000067399.1 | formate hydrogenlyase subunit HycG | - |
| M5S63_RS05325 (1111588) | 1111588..1111998 | + | 411 | WP_001291918.1 | formate hydrogenlyase assembly protein HycH | - |
| M5S63_RS05330 (1111991) | 1111991..1112461 | + | 471 | WP_000132961.1 | hydrogenase maturation peptidase HycI | - |
| M5S63_RS05335 (1112628) | 1112628..1112939 | + | 312 | WP_001521139.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| M5S63_RS05340 (1112936) | 1112936..1113355 | + | 420 | WP_000126294.1 | helix-turn-helix domain-containing protein | Antitoxin |
| M5S63_RS05345 (1113434) | 1113434..1114858 | - | 1425 | WP_020234028.1 | 6-phospho-beta-glucosidase AscB | - |
| M5S63_RS05350 (1114867) | 1114867..1116324 | - | 1458 | WP_020234027.1 | PTS cellobiose/arbutin/salicin transporter subunit IIBC | - |
| M5S63_RS05355 (1116584) | 1116584..1117594 | + | 1011 | WP_015912547.1 | DNA-binding transcriptional regulator AscG | - |
| M5S63_RS05360 (1117743) | 1117743..1118270 | + | 528 | WP_001078777.1 | electron transport protein HydN | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12493.23 Da Isoelectric Point: 9.4783
>T255294 WP_001521139.1 NZ_CP103521:1112628-1112939 [Escherichia coli]
MHIISKAPFEECARKYPNDALALYSLYRVIKETDFSTPEEMRTAFPNLDNFRYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE
MHIISKAPFEECARKYPNDALALYSLYRVIKETDFSTPEEMRTAFPNLDNFRYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15416.42 Da Isoelectric Point: 4.4596
>AT255294 WP_000126294.1 NZ_CP103521:1112936-1113355 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|