Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 731970..732663 Replicon chromosome
Accession NZ_CP103521
Organism Escherichia coli strain 2779 - blood draw same patient as MB9267

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag M5S63_RS03515 Protein ID WP_000415584.1
Coordinates 731970..732266 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M5S63_RS03520 Protein ID WP_000650107.1
Coordinates 732268..732663 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S63_RS03480 (727058) 727058..727372 - 315 WP_000958598.1 putative quinol monooxygenase -
M5S63_RS03485 (727403) 727403..727984 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
M5S63_RS03490 (728303) 728303..728635 + 333 WP_023149630.1 DUF2645 family protein -
M5S63_RS03495 (728681) 728681..730030 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
M5S63_RS03500 (730027) 730027..730686 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
M5S63_RS03505 (730838) 730838..731230 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M5S63_RS03510 (731283) 731283..731765 + 483 WP_000183505.1 GyrI-like domain-containing protein -
M5S63_RS03515 (731970) 731970..732266 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
M5S63_RS03520 (732268) 732268..732663 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M5S63_RS03525 (732796) 732796..734403 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
M5S63_RS03530 (734541) 734541..736799 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T255290 WP_000415584.1 NZ_CP103521:731970-732266 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT255290 WP_000650107.1 NZ_CP103521:732268-732663 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References