Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4789113..4789715 Replicon chromosome
Accession NZ_CP103508
Organism Escherichia coli O25b:H4-ST131 strain 5506

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag M5T03_RS23495 Protein ID WP_000897302.1
Coordinates 4789404..4789715 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5T03_RS23490 Protein ID WP_000356397.1
Coordinates 4789113..4789403 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T03_RS23460 (4784420) 4784420..4785349 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
M5T03_RS23465 (4785531) 4785531..4785773 - 243 WP_001068514.1 CopG family transcriptional regulator -
M5T03_RS23470 (4786063) 4786063..4786911 + 849 WP_001038650.1 hypothetical protein -
M5T03_RS23475 (4786936) 4786936..4787676 + 741 WP_000608806.1 hypothetical protein -
M5T03_RS23480 (4787861) 4787861..4788079 - 219 WP_001251293.1 CopG family transcriptional regulator -
M5T03_RS23485 (4788476) 4788476..4788754 - 279 WP_001296612.1 hypothetical protein -
M5T03_RS23490 (4789113) 4789113..4789403 - 291 WP_000356397.1 NadS family protein Antitoxin
M5T03_RS23495 (4789404) 4789404..4789715 - 312 WP_000897302.1 hypothetical protein Toxin
M5T03_RS23500 (4789944) 4789944..4790852 + 909 WP_001385591.1 alpha/beta hydrolase -
M5T03_RS23505 (4790916) 4790916..4791857 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M5T03_RS23510 (4791902) 4791902..4792339 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
M5T03_RS23515 (4792336) 4792336..4793208 - 873 WP_000920762.1 virulence factor BrkB family protein -
M5T03_RS23520 (4793202) 4793202..4793801 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T255235 WP_000897302.1 NZ_CP103508:c4789715-4789404 [Escherichia coli O25b:H4-ST131]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT255235 WP_000356397.1 NZ_CP103508:c4789403-4789113 [Escherichia coli O25b:H4-ST131]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References