Detailed information of TA system TA255211

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 60165..60429
• Replicon: plasmid pMB9481_2
• Accession: NZ_CP103505
• Organism: Klebsiella pneumoniae strain 5547

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: -
• Locus tag: M5R16_RS27735
• Protein ID: WP_024179505.1
• Coordinates: 60165..60317 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	60369..60429 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M5R16_RS27720 (56997)	56997..57659	+	663	WP_060527638.1	plasmid IncI1-type surface exclusion protein ExcA	-
M5R16_RS27725 (57731)	57731..57940	-	210	WP_000062603.1	HEAT repeat domain-containing protein	-
M5R16_RS27730 (58333)	58333..58509	+	177	WP_180335155.1	hypothetical protein	-
- (59398)	59398..59449	+	52	NuclAT_1	-	-
- (59398)	59398..59449	+	52	NuclAT_1	-	-
- (59398)	59398..59449	+	52	NuclAT_1	-	-
- (59398)	59398..59449	+	52	NuclAT_1	-	-
M5R16_RS27735 (60165)	60165..60317	-	153	WP_024179505.1	Hok/Gef family protein	Toxin
- (60369)	60369..60429	+	61	NuclAT_0	-	Antitoxin
- (60369)	60369..60429	+	61	NuclAT_0	-	Antitoxin
- (60369)	60369..60429	+	61	NuclAT_0	-	Antitoxin
- (60369)	60369..60429	+	61	NuclAT_0	-	Antitoxin
M5R16_RS27740 (60609)	60609..61817	+	1209	WP_064148469.1	IncI1-type conjugal transfer protein TrbA	-
M5R16_RS27745 (61836)	61836..62906	+	1071	WP_064148470.1	IncI1-type conjugal transfer protein TrbB	-
M5R16_RS27750 (62899)	62899..65190	+	2292	WP_077265944.1	F-type conjugative transfer protein TrbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..87513	87513

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5743.07 Da
• Isoelectric Point: 8.7948

>T255211 WP_024179505.1 NZ_CP103505:c60317-60165 [Klebsiella pneumoniae]
MPQRTFLMMLIVVCVTILCFVWIVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 61 bp

>AT255211 NZ_CP103505:60369-60429 [Klebsiella pneumoniae]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Antitoxin