Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3538299..3538974 Replicon chromosome
Accession NZ_CP103494
Organism Enterobacter hormaechei strain 70

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M5T15_RS16840 Protein ID WP_259429671.1
Coordinates 3538299..3538598 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag M5T15_RS16845 Protein ID WP_015571639.1
Coordinates 3538609..3538974 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T15_RS16830 (M5T15_16830) 3534676..3536868 + 2193 WP_032669347.1 type I secretion system permease/ATPase -
M5T15_RS16835 (M5T15_16835) 3536849..3538048 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
M5T15_RS16840 (M5T15_16840) 3538299..3538598 + 300 WP_259429671.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T15_RS16845 (M5T15_16845) 3538609..3538974 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
M5T15_RS16850 (M5T15_16850) 3539001..3540182 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
M5T15_RS16855 (M5T15_16855) 3540203..3541090 - 888 WP_015571641.1 LysR family transcriptional regulator -
M5T15_RS16860 (M5T15_16860) 3541188..3541790 + 603 WP_033487546.1 short chain dehydrogenase -
M5T15_RS16865 (M5T15_16865) 3541787..3542518 - 732 WP_045141885.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11651.31 Da        Isoelectric Point: 9.6776

>T255176 WP_259429671.1 NZ_CP103494:3538299-3538598 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT255176 WP_015571639.1 NZ_CP103494:3538609-3538974 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References