Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1931373..1931875 Replicon chromosome
Accession NZ_CP103465
Organism Escherichia coli O25b:H4-ST131 strain 5392

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag M5T42_RS09150 Protein ID WP_000767822.1
Coordinates 1931621..1931875 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M5T42_RS09145 Protein ID WP_001259255.1
Coordinates 1931373..1931624 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T42_RS09120 (1926551) 1926551..1927618 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M5T42_RS09125 (1927618) 1927618..1928688 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
M5T42_RS09130 (1928685) 1928685..1929989 - 1305 WP_001546022.1 histidinol dehydrogenase -
M5T42_RS09135 (1929995) 1929995..1930894 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M5T42_RS09140 (1931040) 1931040..1931090 - 51 WP_001364200.1 his operon leader peptide -
M5T42_RS09145 (1931373) 1931373..1931624 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M5T42_RS09150 (1931621) 1931621..1931875 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M5T42_RS09155 (1931958) 1931958..1932782 + 825 WP_000754737.1 SDR family oxidoreductase -
M5T42_RS09160 (1932828) 1932828..1933757 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
M5T42_RS09165 (1933972) 1933972..1934034 + 63 WP_010723108.1 membrane protein YoeI -
M5T42_RS09170 (1934024) 1934024..1935382 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T255077 WP_000767822.1 NZ_CP103465:1931621-1931875 [Escherichia coli O25b:H4-ST131]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT255077 WP_001259255.1 NZ_CP103465:1931373-1931624 [Escherichia coli O25b:H4-ST131]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References