Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 19002..19726 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP103422 | ||
| Organism | Klebsiella variicola strain KV1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A2J4YLV3 |
| Locus tag | NYO12_RS29845 | Protein ID | WP_023292165.1 |
| Coordinates | 19415..19726 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NYO12_RS29840 | Protein ID | WP_023292164.1 |
| Coordinates | 19002..19418 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NYO12_RS29825 (NYO12_29825) | 14436..15005 | - | 570 | WP_259075151.1 | fertility inhibition protein FinO | - |
| NYO12_RS29830 (NYO12_29830) | 15105..15827 | - | 723 | WP_259075153.1 | type-F conjugative transfer system pilin acetylase TraX | - |
| NYO12_RS29835 (NYO12_29835) | 15907..18615 | - | 2709 | Protein_15 | AAA family ATPase | - |
| NYO12_RS29840 (NYO12_29840) | 19002..19418 | - | 417 | WP_023292164.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NYO12_RS29845 (NYO12_29845) | 19415..19726 | - | 312 | WP_023292165.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NYO12_RS29850 (NYO12_29850) | 19962..21449 | - | 1488 | WP_161267625.1 | group II intron reverse transcriptase/maturase | - |
| NYO12_RS29855 (NYO12_29855) | 21855..22283 | + | 429 | WP_259075156.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NYO12_RS29860 (NYO12_29860) | 22283..23554 | + | 1272 | WP_259075159.1 | Y-family DNA polymerase | - |
| NYO12_RS29865 (NYO12_29865) | 23636..24610 | - | 975 | WP_001568034.1 | ParB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..81805 | 81805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12497.32 Da Isoelectric Point: 9.9242
>T255045 WP_023292165.1 NZ_CP103422:c19726-19415 [Klebsiella variicola]
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
Download Length: 312 bp
Antitoxin
Download Length: 139 a.a. Molecular weight: 15462.59 Da Isoelectric Point: 4.4720
>AT255045 WP_023292164.1 NZ_CP103422:c19418-19002 [Klebsiella variicola]
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLAARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMRQYGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLAARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMRQYGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
Download Length: 417 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|