Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4074454..4075051 Replicon chromosome
Accession NZ_CP103419
Organism Klebsiella variicola strain KV4

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag NYO13_RS19690 Protein ID WP_012542526.1
Coordinates 4074734..4075051 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYO13_RS19685 Protein ID WP_012542525.1
Coordinates 4074454..4074741 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO13_RS19655 (NYO13_19655) 4070276..4070524 + 249 WP_008805539.1 DUF1158 domain-containing protein -
NYO13_RS19660 (NYO13_19660) 4070541..4070882 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
NYO13_RS19665 (NYO13_19665) 4070913..4072028 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
NYO13_RS19670 (NYO13_19670) 4072208..4072789 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
NYO13_RS19675 (NYO13_19675) 4072789..4073157 + 369 WP_259144806.1 MmcQ/YjbR family DNA-binding protein -
NYO13_RS19680 (NYO13_19680) 4073277..4073930 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
NYO13_RS19685 (NYO13_19685) 4074454..4074741 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
NYO13_RS19690 (NYO13_19690) 4074734..4075051 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYO13_RS19695 (NYO13_19695) 4075236..4076279 - 1044 WP_048330781.1 DUF2157 domain-containing protein -
NYO13_RS19700 (NYO13_19700) 4076942..4077808 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
NYO13_RS19705 (NYO13_19705) 4077917..4079344 + 1428 WP_048330780.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T255024 WP_012542526.1 NZ_CP103419:c4075051-4074734 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT255024 WP_012542525.1 NZ_CP103419:c4074741-4074454 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References