Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1794919..1795579 Replicon chromosome
Accession NZ_CP103419
Organism Klebsiella variicola strain KV4

Toxin (Protein)


Gene name higB Uniprot ID A0A8B6IX92
Locus tag NYO13_RS08615 Protein ID WP_008804168.1
Coordinates 1795226..1795579 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYO13_RS08610 Protein ID WP_032700907.1
Coordinates 1794919..1795221 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO13_RS08575 (NYO13_08575) 1790264..1791364 - 1101 WP_048330526.1 AarF/UbiB family protein -
NYO13_RS08580 (NYO13_08580) 1791891..1792148 + 258 WP_012541132.1 antitoxin -
NYO13_RS08585 (NYO13_08585) 1792149..1792481 + 333 WP_008804165.1 type II toxin-antitoxin system PemK/MazF family toxin -
NYO13_RS08595 (NYO13_08595) 1792804..1794240 + 1437 WP_259145131.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
NYO13_RS08605 (NYO13_08605) 1794566..1794715 - 150 Protein_1683 antitoxin -
NYO13_RS08610 (NYO13_08610) 1794919..1795221 - 303 WP_032700907.1 XRE family transcriptional regulator Antitoxin
NYO13_RS08615 (NYO13_08615) 1795226..1795579 - 354 WP_008804168.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYO13_RS08620 (NYO13_08620) 1795783..1797264 + 1482 WP_008804169.1 hypothetical protein -
NYO13_RS08625 (NYO13_08625) 1797353..1798807 - 1455 WP_008804170.1 AMP nucleosidase -
NYO13_RS08630 (NYO13_08630) 1798938..1799183 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13528.51 Da        Isoelectric Point: 10.1729

>T255018 WP_008804168.1 NZ_CP103419:c1795579-1795226 [Klebsiella variicola]
VWTIKTTDMFDRWFTSLNDIDRASVLAALLVLREKGPGLSRPYADTIRGSRYSNMKELRVQSRGDPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYHEMLAVADREFTNWLNRLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11134.95 Da        Isoelectric Point: 5.7424

>AT255018 WP_032700907.1 NZ_CP103419:c1795221-1794919 [Klebsiella variicola]
MGRTLEQLLIDEKPDVVAEAQAIAKDILLNIHLAELREKVQKTQVEMAQNLGIKQPTVAGMEKPGRDLKLSTLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6IX92

Antitoxin

Source ID Structure

References