Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4237..4888 Replicon plasmid pAB2369-2
Accession NZ_CP103415
Organism Acinetobacter baumannii strain AB2369

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag NX832_RS19020 Protein ID WP_000269904.1
Coordinates 4237..4593 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NX832_RS19025 Protein ID WP_001129974.1
Coordinates 4586..4888 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX832_RS19000 (NX832_19000) 427..1218 + 792 WP_259024969.1 hypothetical protein -
NX832_RS19005 (NX832_19005) 1631..2566 + 936 WP_001292329.1 replication initiation protein RepM -
NX832_RS19010 (NX832_19010) 2644..3162 + 519 WP_000839337.1 plasmid replication DNA-binding protein -
NX832_RS19015 (NX832_19015) 3372..3671 + 300 WP_000358348.1 hypothetical protein -
NX832_RS19020 (NX832_19020) 4237..4593 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NX832_RS19025 (NX832_19025) 4586..4888 + 303 WP_001129974.1 XRE family transcriptional regulator Antitoxin
NX832_RS19030 (NX832_19030) 4881..5090 + 210 WP_000069474.1 hypothetical protein -
NX832_RS19035 (NX832_19035) 5416..5877 - 462 WP_000761346.1 DIP1984 family protein -
NX832_RS19040 (NX832_19040) 6182..8593 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
NX832_RS19045 (NX832_19045) 8721..9035 - 315 WP_001983304.1 BrnA antitoxin family protein -
NX832_RS19050 (NX832_19050) 9022..9309 - 288 WP_000438827.1 BrnT family toxin -
NX832_RS19055 (NX832_19055) 9577..9876 - 300 WP_000358348.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11192 11192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T255011 WP_000269904.1 NZ_CP103415:4237-4593 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11150.97 Da        Isoelectric Point: 7.3198

>AT255011 WP_001129974.1 NZ_CP103415:4586-4888 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8YFZ1

Antitoxin

Source ID Structure

References