Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4586..5237 Replicon plasmid pAB2369-1
Accession NZ_CP103414
Organism Acinetobacter baumannii strain AB2369

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag NX832_RS18960 Protein ID WP_000269904.1
Coordinates 4881..5237 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NX832_RS18955 Protein ID WP_001129974.1
Coordinates 4586..4888 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX832_RS18930 (NX832_18930) 166..452 + 287 Protein_0 BrnT family toxin -
NX832_RS18935 (NX832_18935) 439..753 + 315 WP_001983304.1 BrnA antitoxin family protein -
NX832_RS18940 (NX832_18940) 881..3292 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
NX832_RS18945 (NX832_18945) 3597..4058 + 462 WP_000761346.1 DIP1984 family protein -
NX832_RS18950 (NX832_18950) 4384..4593 - 210 WP_000069474.1 hypothetical protein -
NX832_RS18955 (NX832_18955) 4586..4888 - 303 WP_001129974.1 XRE family transcriptional regulator Antitoxin
NX832_RS18960 (NX832_18960) 4881..5237 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NX832_RS18965 (NX832_18965) 5803..6102 - 300 WP_000358348.1 hypothetical protein -
NX832_RS18970 (NX832_18970) 6219..6980 - 762 WP_000425105.1 hypothetical protein -
NX832_RS18975 (NX832_18975) 7285..8454 + 1170 WP_002134206.1 MobA/MobL family protein -
NX832_RS18980 (NX832_18980) 9051..9986 + 936 WP_001292329.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11193 11193


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T255010 WP_000269904.1 NZ_CP103414:c5237-4881 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11150.97 Da        Isoelectric Point: 7.3198

>AT255010 WP_001129974.1 NZ_CP103414:c4888-4586 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8YFZ1

Antitoxin

Source ID Structure

References