Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1523521..1524181 Replicon chromosome
Accession NZ_CP103401
Organism Pantoea agglomerans strain CHTF15

Toxin (Protein)


Gene name higB Uniprot ID A0A349IFT5
Locus tag NYF24_RS06965 Protein ID WP_010670918.1
Coordinates 1523521..1523874 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYF24_RS06970 Protein ID WP_010247918.1
Coordinates 1523879..1524181 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYF24_RS06945 (1518718) 1518718..1518999 + 282 WP_187492155.1 hypothetical protein -
NYF24_RS06950 (1519098) 1519098..1519499 + 402 WP_010247930.1 cell envelope integrity TolA C-terminal domain-containing protein -
NYF24_RS06955 (1519576) 1519576..1521738 - 2163 WP_258995149.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
NYF24_RS06960 (1522134) 1522134..1523222 + 1089 WP_258995151.1 YncE family protein -
NYF24_RS06965 (1523521) 1523521..1523874 + 354 WP_010670918.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYF24_RS06970 (1523879) 1523879..1524181 + 303 WP_010247918.1 XRE family transcriptional regulator Antitoxin
NYF24_RS06980 (1524853) 1524853..1525776 + 924 WP_010247907.1 sugar ABC transporter substrate-binding protein -
NYF24_RS06985 (1525809) 1525809..1527293 + 1485 WP_010247905.1 sugar ABC transporter ATP-binding protein -
NYF24_RS06990 (1527317) 1527317..1528342 + 1026 WP_174819610.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13649.71 Da        Isoelectric Point: 8.4949

>T254993 WP_010670918.1 NZ_CP103401:1523521-1523874 [Pantoea agglomerans]
VWMIKTTERFDRWFTLLNESDRACVLAALMVLREKGPGLSRPYADTLKGSVYINMKELRIQSRGDPIRAFFAFDPNRTAI
VLCAGNKVGNEKRFYQEMLPVADREFTHWLNSFKDEE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10941.72 Da        Isoelectric Point: 5.7251

>AT254993 WP_010247918.1 NZ_CP103401:1523879-1524181 [Pantoea agglomerans]
MGRTLEQLIADEKPEVVADAQAMATDILLNIHLAELREKVQKTQVEMAKALGITQPTVAGMEKPGRDLKLSTLKRYIDAA
GGKLRLVVELPDGSHYGFEV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A349IFT5

Antitoxin

Source ID Structure

References