Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4536..5121 Replicon plasmid unnamed4
Accession NZ_CP103341
Organism Acinetobacter baumannii strain AB105

Toxin (Protein)


Gene name higB Uniprot ID A0A3F3L0E6
Locus tag NT399_RS18275 Protein ID WP_002126330.1
Coordinates 4801..5121 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NT399_RS18270 Protein ID WP_002126333.1
Coordinates 4536..4808 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT399_RS18230 (NT399_18230) 1..933 + 933 WP_002124966.1 replication initiation protein RepM -
NT399_RS18235 (NT399_18235) 993..1553 + 561 WP_223154292.1 plasmid replication DNA-binding protein -
NT399_RS18240 (NT399_18240) 1566..1709 + 144 WP_001125247.1 hypothetical protein -
NT399_RS18245 (NT399_18245) 1899..2282 + 384 WP_038343695.1 hypothetical protein -
NT399_RS18250 (NT399_18250) 2512..2799 + 288 WP_002124950.1 BrnT family toxin -
NT399_RS18255 (NT399_18255) 2786..3097 + 312 WP_004836815.1 BrnA antitoxin family protein -
NT399_RS18260 (NT399_18260) 3204..3665 - 462 WP_002124952.1 hypothetical protein -
NT399_RS18265 (NT399_18265) 3658..4359 - 702 WP_002124954.1 serine protease -
NT399_RS18270 (NT399_18270) 4536..4808 - 273 WP_002126333.1 NadS family protein Antitoxin
NT399_RS18275 (NT399_18275) 4801..5121 - 321 WP_002126330.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NT399_RS18280 (NT399_18280) 5293..5721 + 429 WP_002125445.1 hypothetical protein -
NT399_RS18285 (NT399_18285) 5787..5978 - 192 WP_002125028.1 hypothetical protein -
NT399_RS18290 (NT399_18290) 7347..8270 + 924 WP_000845851.1 replication initiation protein RepM -
NT399_RS18295 (NT399_18295) 8338..8883 + 546 WP_000736775.1 plasmid replication DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..13439 13439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12191.98 Da        Isoelectric Point: 7.9834

>T254966 WP_002126330.1 NZ_CP103341:c5121-4801 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVNEDDQIFFLVAY
PKSVKDNLTDKETAILRQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10177.62 Da        Isoelectric Point: 9.8622

>AT254966 WP_002126333.1 NZ_CP103341:c4808-4536 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEIQASRTTELKLPDIKEVREKTGLSQSEFAARLHISHRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3F3L0E6

Antitoxin

Source ID Structure

References