Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 18068..18719 Replicon plasmid unnamed3
Accession NZ_CP103340
Organism Acinetobacter baumannii strain AB105

Toxin (Protein)


Gene name higB Uniprot ID A0A3R9RP36
Locus tag NT399_RS18085 Protein ID WP_068520067.1
Coordinates 18363..18719 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NT399_RS18080 Protein ID WP_001140620.1
Coordinates 18068..18370 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT399_RS18060 (NT399_18060) 13424..13813 - 390 WP_004781111.1 tautomerase family protein -
NT399_RS18065 (NT399_18065) 14011..15687 - 1677 WP_024437862.1 AlwI family type II restriction endonuclease -
NT399_RS18070 (NT399_18070) 15735..17657 - 1923 WP_024437863.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
NT399_RS18075 (NT399_18075) 17650..17901 - 252 WP_114889766.1 XRE family transcriptional regulator -
NT399_RS18080 (NT399_18080) 18068..18370 - 303 WP_001140620.1 XRE family transcriptional regulator Antitoxin
NT399_RS18085 (NT399_18085) 18363..18719 - 357 WP_068520067.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NT399_RS18090 (NT399_18090) 19455..21509 + 2055 WP_004740259.1 TonB-dependent receptor -
NT399_RS18095 (NT399_18095) 21623..22309 + 687 WP_004740261.1 DUF4145 domain-containing protein -
NT399_RS18100 (NT399_18100) 22351..22458 + 108 Protein_25 transcriptional regulator -
NT399_RS18105 (NT399_18105) 22656..22991 + 336 WP_004740263.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..50018 50018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13572.58 Da        Isoelectric Point: 7.1650

>T254964 WP_068520067.1 NZ_CP103340:c18719-18363 [Acinetobacter baumannii]
MWTVITTDLFNQWLEQQEESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIADKGGKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11227.02 Da        Isoelectric Point: 6.4759

>AT254964 WP_001140620.1 NZ_CP103340:c18370-18068 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9RP36

Antitoxin

Source ID Structure

References