254962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1835465..1836116 Replicon chromosome
Accession NZ_CP103338
Organism Acinetobacter baumannii strain AB105

Toxin (Protein)


Gene name higB Uniprot ID S3SZA7
Locus tag NT399_RS08810 Protein ID WP_000269903.1
Coordinates 1835760..1836116 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NT399_RS08805 Protein ID WP_001140619.1
Coordinates 1835465..1835767 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT399_RS08775 (NT399_08775) 1830550..1830901 - 352 Protein_1709 transposase -
NT399_RS08780 (NT399_08780) 1831044..1831292 + 249 WP_002084120.1 diguanylate cyclase -
NT399_RS08785 (NT399_08785) 1831304..1831792 + 489 WP_038342305.1 phosphate-starvation-inducible PsiE family protein -
NT399_RS08790 (NT399_08790) 1831779..1832589 + 811 Protein_1712 zinc metalloprotease HtpX -
NT399_RS08795 (NT399_08795) 1832609..1833760 + 1152 WP_188198428.1 trypsin-like peptidase domain-containing protein -
NT399_RS08800 (NT399_08800) 1834342..1835274 - 933 WP_049590625.1 IS5-like element ISAba13 family transposase -
NT399_RS08805 (NT399_08805) 1835465..1835767 - 303 WP_001140619.1 XRE family transcriptional regulator Antitoxin
NT399_RS08810 (NT399_08810) 1835760..1836116 - 357 WP_000269903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NT399_RS08815 (NT399_08815) 1836666..1837991 - 1326 Protein_1717 ISNCY family transposase -
NT399_RS08820 (NT399_08820) 1838548..1840809 + 2262 WP_000167003.1 excinuclease ABC subunit UvrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1804735..1837667 32932
- inside IScluster/Tn - - 1834342..1837667 3325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13486.45 Da        Isoelectric Point: 7.1645

>T254962 WP_000269903.1 NZ_CP103338:c1836116-1835760 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT254962 WP_001140619.1 NZ_CP103338:c1835767-1835465 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836MG83

Antitoxin

Source ID Structure

References