Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 647522..648321 Replicon chromosome
Accession NZ_CP103329
Organism Escherichia coli strain ZY22049

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NX000_RS03170 Protein ID WP_000347251.1
Coordinates 647522..647986 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NX000_RS03175 Protein ID WP_001307405.1
Coordinates 647986..648321 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX000_RS03140 (642523) 642523..642957 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NX000_RS03145 (642975) 642975..643853 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NX000_RS03150 (643843) 643843..644622 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NX000_RS03155 (644633) 644633..645106 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NX000_RS03160 (645129) 645129..646409 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
NX000_RS03165 (646658) 646658..647467 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NX000_RS03170 (647522) 647522..647986 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NX000_RS03175 (647986) 647986..648321 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NX000_RS03180 (648470) 648470..650041 - 1572 WP_001273761.1 galactarate dehydratase -
NX000_RS03185 (650416) 650416..651750 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
NX000_RS03190 (651766) 651766..652536 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T254933 WP_000347251.1 NZ_CP103329:c647986-647522 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT254933 WP_001307405.1 NZ_CP103329:c648321-647986 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References