Detailed information of TA system TA025492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1813707..1814219
• Replicon: chromosome
• Accession: NC_015760
• Organism: Streptococcus salivarius CCHSS3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: F8HFZ9
• Locus tag: SALIVB_RS08255
• Protein ID: WP_008535398.1
• Coordinates: 1813707..1813961 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: SALIVB_RS08260
• Protein ID: WP_013991075.1
• Coordinates: 1813965..1814219 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SALIVB_RS10895	1808966..1809133	-	168	WP_013991072.1	hypothetical protein	-
SALIVB_RS08245	1809710..1810318	-	609	WP_013991073.1	DUF4230 domain-containing protein	-
SALIVB_RS08250	1810897..1813002	-	2106	WP_013991074.1	ATP-dependent Clp protease ATP-binding subunit	-
SALIVB_RS08255	1813707..1813961	-	255	WP_008535398.1	Txe/YoeB family addiction module toxin	Toxin
SALIVB_RS08260	1813965..1814219	-	255	WP_013991075.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SALIVB_RS08265	1814360..1815451	-	1092	WP_013991076.1	nucleotidyltransferase	-
SALIVB_RS08270	1815457..1816203	-	747	WP_172633789.1	class I SAM-dependent methyltransferase	-
SALIVB_RS08275	1816516..1816869	-	354	WP_013991078.1	ribosome silencing factor	-
SALIVB_RS08280	1816892..1817482	-	591	WP_013991079.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
SALIVB_RS08285	1817479..1818111	-	633	WP_002884372.1	nicotinate-nucleotide adenylyltransferase	-
SALIVB_RS08290	1818219..1818536	-	318	WP_002884193.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10097.52 Da
• Isoelectric Point: 8.8499

>T25492 WP_008535398.1 NC_015760:c1813961-1813707 [Streptococcus salivarius CCHSS3]
MLLTFTEDAWTDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMVDGKSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T25492 NC_015760:c1813961-1813707 [Streptococcus salivarius CCHSS3]
ATGTTACTCACTTTTACTGAAGATGCATGGACAGATTATTGTTATTGGCAAAATCAAGATAGGAAGACACTTAAGCGAAT
CAATAAGCTGATTAAAGACATTCAACGGGATCCTTTTTCAGGTATTGGGAAACCAGAACCCTTGAAGTATGACTTTCAAG
GAGCTTGGTCTCGACGAATTGATGCTGAAAATCGTTTGATTTATATGGTTGATGGTAAGAGTGTCGCCTTTCTCTCTTTC
AAAGATCATTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9719.00 Da
• Isoelectric Point: 4.8782

>AT25492 WP_013991075.1 NC_015760:c1814219-1813965 [Streptococcus salivarius CCHSS3]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGETQEH
AIKE

Nucleotide

• Length: 255 bp

>AT25492 NC_015760:c1814219-1813965 [Streptococcus salivarius CCHSS3]
ATGGAAGCAGTCGTCTATTCAACATTTCGAAATCATTTAAAGGATTATATGAAGAAGGTTAATGATGAATTTGAACCTCT
AGCTGTAGTCAATAAAAATCCTGATGAAGATATTGTAGTGGTCTCAAAGAGTGAATGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAACAT
GCAATAAAGGAGTAG

Structures

Toxin

• AlphaFold DB: F8HFZ9