Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743717..744492 Replicon chromosome
Accession NZ_CP103315
Organism Klebsiella pneumoniae strain hvKP12

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NXZ72_RS03720 Protein ID WP_004150910.1
Coordinates 744007..744492 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NXZ72_RS03715 Protein ID WP_004150912.1
Coordinates 743717..744010 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ72_RS03695 (NXZ72_03695) 738925..739527 - 603 WP_062954968.1 short chain dehydrogenase -
NXZ72_RS03700 (NXZ72_03700) 739625..740536 + 912 WP_004188550.1 LysR family transcriptional regulator -
NXZ72_RS03705 (NXZ72_03705) 740537..741685 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NXZ72_RS03710 (NXZ72_03710) 741696..743072 - 1377 WP_004217775.1 cystathionine beta-synthase -
NXZ72_RS03715 (NXZ72_03715) 743717..744010 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NXZ72_RS03720 (NXZ72_03720) 744007..744492 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NXZ72_RS03725 (NXZ72_03725) 745196..745789 + 594 WP_004188553.1 hypothetical protein -
NXZ72_RS03730 (NXZ72_03730) 745886..746102 + 217 Protein_733 transposase -
NXZ72_RS03735 (NXZ72_03735) 746708..747580 + 873 WP_004188557.1 ParA family protein -
NXZ72_RS03740 (NXZ72_03740) 747580..747963 + 384 WP_004150906.1 hypothetical protein -
NXZ72_RS03745 (NXZ72_03745) 747956..749323 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 745886..746038 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T254912 WP_004150910.1 NZ_CP103315:744007-744492 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT254912 WP_004150912.1 NZ_CP103315:743717-744010 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References