Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5237686..5238281 Replicon chromosome
Accession NZ_CP103307
Organism Pseudomonas aeruginosa strain PLL01

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag NX763_RS24275 Protein ID WP_003113526.1
Coordinates 5238003..5238281 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NX763_RS24270 Protein ID WP_003113527.1
Coordinates 5237686..5237991 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX763_RS24235 (NX763_24235) 5232825..5233673 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
NX763_RS24245 (NX763_24245) 5233840..5234781 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
NX763_RS24250 (NX763_24250) 5234898..5235512 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
NX763_RS24255 (NX763_24255) 5235554..5236138 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
NX763_RS24260 (NX763_24260) 5236179..5237279 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
NX763_RS24270 (NX763_24270) 5237686..5237991 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
NX763_RS24275 (NX763_24275) 5238003..5238281 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NX763_RS24280 (NX763_24280) 5238334..5238462 - 129 Protein_4795 integrase -
NX763_RS24285 (NX763_24285) 5238610..5240838 + 2229 WP_003113525.1 TonB-dependent receptor -
NX763_RS24290 (NX763_24290) 5240908..5241555 - 648 WP_003095021.1 carbonate dehydratase -
NX763_RS24295 (NX763_24295) 5241617..5242855 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T254906 WP_003113526.1 NZ_CP103307:c5238281-5238003 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT254906 WP_003113527.1 NZ_CP103307:c5237991-5237686 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References