Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4320247..4320983 Replicon chromosome
Accession NZ_CP103300
Organism Endozoicomonas euniceicola strain EF212

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NX720_RS17325 Protein ID WP_262596235.1
Coordinates 4320247..4320561 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NX720_RS17330 Protein ID WP_262596237.1
Coordinates 4320558..4320983 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX720_RS17305 (NX720_17305) 4316910..4317506 + 597 WP_262596229.1 SPOR domain-containing protein -
NX720_RS17310 (NX720_17310) 4317586..4318146 + 561 WP_262596231.1 ATP-dependent protease subunit HslV -
NX720_RS17315 (NX720_17315) 4318224..4319564 + 1341 WP_262601602.1 HslU--HslV peptidase ATPase subunit -
NX720_RS17320 (NX720_17320) 4319675..4320145 + 471 WP_262596233.1 GNAT family N-acetyltransferase -
NX720_RS17325 (NX720_17325) 4320247..4320561 + 315 WP_262596235.1 type II toxin-antitoxin system HigB family toxin Toxin
NX720_RS17330 (NX720_17330) 4320558..4320983 + 426 WP_262596237.1 transcriptional regulator Antitoxin
NX720_RS17335 (NX720_17335) 4321324..4323060 + 1737 WP_262596239.1 MOSC domain-containing protein -
NX720_RS17340 (NX720_17340) 4323206..4323763 + 558 WP_262601603.1 DUF917 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4320247..4338101 17854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(7-139)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12025.79 Da        Isoelectric Point: 9.7749

>T254897 WP_262596235.1 NZ_CP103300:4320247-4320561 [Endozoicomonas euniceicola]
MHVISRKPFNEAVKKYPNDAAAIDAAYKSLRNGDFHSPGDLKSLFPSLDNFKYKDKWWVIDIGGNNLRLIAFIEFRDSRM
YVKHIVTHAEYDKLCKKYAKEAGS

Download         Length: 315 bp

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 16359.44 Da        Isoelectric Point: 4.4555

>AT254897 WP_262596237.1 NZ_CP103300:4320558-4320983 [Endozoicomonas euniceicola]
MRFSNLKQKAVDFFSEARFVGRIHNEAEYEQALELMDDLIEDYDKYLPLIEVLSASIEKWEDESEQFSEFNKRIETLDDG
VAILRTIMDQYQLKADDLKNELGSKSLVSMILNGSRNLTRDHIQALSQRFKISPSVFFNGA

Download         Length: 426 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References