Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4285132..4285825 Replicon chromosome
Accession NZ_CP103295
Organism Escherichia coli strain 2e

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag NW892_RS20550 Protein ID WP_000415585.1
Coordinates 4285529..4285825 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NW892_RS20545 Protein ID WP_000650107.1
Coordinates 4285132..4285527 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW892_RS20535 (4280996) 4280996..4283254 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
NW892_RS20540 (4283392) 4283392..4284999 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
NW892_RS20545 (4285132) 4285132..4285527 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NW892_RS20550 (4285529) 4285529..4285825 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
NW892_RS20555 (4286030) 4286030..4286512 - 483 WP_000183505.1 GyrI-like domain-containing protein -
NW892_RS20560 (4286565) 4286565..4286957 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NW892_RS20565 (4287109) 4287109..4287768 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
NW892_RS20570 (4287765) 4287765..4289114 + 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
NW892_RS20575 (4289160) 4289160..4289492 - 333 WP_000914690.1 DUF2645 family protein -
NW892_RS20580 (4289499) 4289499..4290209 - 711 WP_000834030.1 hypothetical protein -
NW892_RS20585 (4290181) 4290181..4290690 - 510 WP_231364094.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T254873 WP_000415585.1 NZ_CP103295:c4285825-4285529 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT254873 WP_000650107.1 NZ_CP103295:c4285527-4285132 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References