254859

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1604037..1604551 Replicon chromosome
Accession NZ_CP103293
Organism Limosilactobacillus fermentum strain LfU21

Toxin (Protein)


Gene name yoeB Uniprot ID A0A806T892
Locus tag C0965_RS08255 Protein ID WP_021350110.1
Coordinates 1604037..1604300 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag C0965_RS08260 Protein ID WP_003684069.1
Coordinates 1604297..1604551 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0965_RS08240 (C0965_008240) 1599517..1600299 + 783 WP_035437193.1 arginine deiminase-related protein -
C0965_RS08245 (C0965_008245) 1600687..1602084 + 1398 WP_003684076.1 Na+/H+ antiporter NhaC family protein -
C0965_RS08250 (C0965_008250) 1602510..1603631 + 1122 WP_021350111.1 PTS sugar transporter subunit IIC -
C0965_RS08255 (C0965_008255) 1604037..1604300 - 264 WP_021350110.1 Txe/YoeB family addiction module toxin Toxin
C0965_RS08260 (C0965_008260) 1604297..1604551 - 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C0965_RS08265 (C0965_008265) 1604869..1606089 + 1221 WP_021349406.1 IS256 family transposase -
C0965_RS08270 (C0965_008270) 1606207..1606698 + 492 WP_259359296.1 helix-turn-helix domain-containing protein -
C0965_RS08275 (C0965_008275) 1606754..1607602 + 849 WP_259359338.1 IS3 family transposase -
C0965_RS08280 (C0965_008280) 1607637..1608173 + 537 WP_259359297.1 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10262.99 Da        Isoelectric Point: 10.7050

>T254859 WP_021350110.1 NZ_CP103293:c1604300-1604037 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHNR

Download         Length: 264 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT254859 WP_003684069.1 NZ_CP103293:c1604551-1604297 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806T892

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References