Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 332124..332710 Replicon chromosome
Accession NZ_CP102987
Organism Klebsiella pneumoniae strain KPA2

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag NW253_RS01535 Protein ID WP_002920800.1
Coordinates 332342..332710 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag NW253_RS01530 Protein ID WP_004174006.1
Coordinates 332124..332345 (+) Length 74 a.a.

Genomic Context


NW253_RS01510NW253_RS01515NW253_RS01520NW253_RS01525NW253_RS01530NW253_RS01535NW253_RS01540NW253_RS01545NW253_RS01550NW253_RS01555
Location: 328281..329207 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 329204..330481 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Location: 330478..331245 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 331247..331960 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 332124..332345 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 332342..332710 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 332983..334299 (1317 bp)
Type: Others
Protein ID: WP_004174008.1
Location: 334406..335293 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 335290..336135 (846 bp)
Type: Others
Protein ID: WP_004145129.1
Location: 336137..337207 (1071 bp)
Type: Others
Protein ID: WP_032433652.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW253_RS01510 (328281)328281..329207+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
NW253_RS01515 (329204)329204..330481+1278WP_004174005.1branched chain amino acid ABC transporter permease LivM-
NW253_RS01520 (330478)330478..331245+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
NW253_RS01525 (331247)331247..331960+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
NW253_RS01530 (332124)332124..332345+222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
NW253_RS01535 (332342)332342..332710+369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
NW253_RS01540 (332983)332983..334299+1317WP_004174008.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
NW253_RS01545 (334406)334406..335293+888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
NW253_RS01550 (335290)335290..336135+846WP_004145129.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
NW253_RS01555 (336137)336137..337207+1071WP_032433652.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--329204..3379448740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-50)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T254791 WP_002920800.1 NZ_CP102987:332342-332710 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp


Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT254791 WP_004174006.1 NZ_CP102987:332124-332345 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GUD1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References