Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2446172..2446695 Replicon chromosome
Accession NZ_CP102977
Organism Staphylococcus aureus strain 27-G-H

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag NW957_RS12145 Protein ID WP_000074043.1
Coordinates 2446172..2446438 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NW957_RS12150 Protein ID WP_000587618.1
Coordinates 2446438..2446695 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW957_RS12125 (2441478) 2441478..2442665 - 1188 WP_000026187.1 MFS transporter -
NW957_RS12130 (2443061) 2443061..2443837 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW957_RS12135 (2443830) 2443830..2444492 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
NW957_RS12140 (2444740) 2444740..2445816 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW957_RS12145 (2446172) 2446172..2446438 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
NW957_RS12150 (2446438) 2446438..2446695 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW957_RS12155 (2447054) 2447054..2447509 + 456 WP_000732091.1 DUF1307 domain-containing protein -
NW957_RS12160 (2447677) 2447677..2449254 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
NW957_RS12165 (2449450) 2449450..2450199 + 750 WP_165468804.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T254790 WP_000074043.1 NZ_CP102977:c2446438-2446172 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT254790 WP_000587618.1 NZ_CP102977:c2446695-2446438 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References