Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2389199..2389716 Replicon chromosome
Accession NZ_CP102977
Organism Staphylococcus aureus strain 27-G-H

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW957_RS11870 Protein ID WP_000113262.1
Coordinates 2389199..2389465 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW957_RS11875 Protein ID WP_000584499.1
Coordinates 2389465..2389716 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW957_RS11840 (2384625) 2384625..2385161 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW957_RS11845 (2385395) 2385395..2386219 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW957_RS11850 (2386436) 2386436..2386618 - 183 WP_000079140.1 hypothetical protein -
NW957_RS11855 (2386705) 2386705..2387172 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW957_RS11860 (2387358) 2387358..2388905 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW957_RS11865 (2389093) 2389093..2389164 - 72 WP_223200558.1 hypothetical protein -
NW957_RS11870 (2389199) 2389199..2389465 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW957_RS11875 (2389465) 2389465..2389716 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW957_RS11880 (2389881) 2389881..2389961 - 81 WP_223197974.1 hypothetical protein -
NW957_RS11885 (2389989) 2389989..2390588 - 600 WP_000162810.1 DsbA family protein -
NW957_RS11890 (2390607) 2390607..2390969 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW957_RS11895 (2391224) 2391224..2392474 + 1251 WP_165468816.1 FemA/FemB family glycyltransferase FmhA -
NW957_RS11900 (2392571) 2392571..2393302 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW957_RS11905 (2393299) 2393299..2394018 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254788 WP_000113262.1 NZ_CP102977:c2389465-2389199 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254788 WP_000584499.1 NZ_CP102977:c2389716-2389465 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References