Detailed information of TA system TA254780

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1952993..1953258
• Replicon: chromosome
• Accession: NZ_CP102977
• Organism: Staphylococcus aureus strain 27-G-H

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NW957_RS09550
• Protein ID: WP_000880504.1
• Coordinates: 1953124..1953258 (-)
• Length: 45 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1952993..1953132 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW957_RS09510 (1948337)	1948337..1948597	+	261	WP_001791826.1	hypothetical protein	-
NW957_RS09515 (1948650)	1948650..1949000	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
NW957_RS09520 (1949682)	1949682..1950131	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
NW957_RS09525 (1950224)	1950224..1950558	-	335	Protein_1835	SH3 domain-containing protein	-
NW957_RS09530 (1951209)	1951209..1951700	-	492	WP_000920041.1	staphylokinase	-
NW957_RS09535 (1951891)	1951891..1952646	-	756	WP_000861038.1	CHAP domain-containing protein	-
NW957_RS09540 (1952658)	1952658..1952912	-	255	WP_000611512.1	phage holin	-
NW957_RS09545 (1952964)	1952964..1953071	+	108	WP_031762631.1	hypothetical protein	-
- (1952993)	1952993..1953132	+	140	NuclAT_0	-	Antitoxin
- (1952993)	1952993..1953132	+	140	NuclAT_0	-	Antitoxin
- (1952993)	1952993..1953132	+	140	NuclAT_0	-	Antitoxin
- (1952993)	1952993..1953132	+	140	NuclAT_0	-	Antitoxin
NW957_RS09550 (1953124)	1953124..1953258	-	135	WP_000880504.1	type I toxin-antitoxin system toxin PepG1	Toxin
NW957_RS09555 (1953443)	1953443..1953817	-	375	WP_000340977.1	hypothetical protein	-
NW957_RS09560 (1953873)	1953873..1954160	-	288	WP_001262620.1	hypothetical protein	-
NW957_RS09565 (1954206)	1954206..1954358	-	153	WP_001000058.1	hypothetical protein	-
NW957_RS09570 (1954351)	1954351..1958133	-	3783	WP_000582177.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1948650..1999647	50997

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (16-44)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 5043.38 Da
• Isoelectric Point: 11.7213

>T254780 WP_000880504.1 NZ_CP102977:c1953258-1953124 [Staphylococcus aureus]
MLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 135 bp

>T254780 NZ_CP102977:c1953258-1953124 [Staphylococcus aureus]
ATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCTAATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCT
TATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAATTAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT254780 NZ_CP102977:1952993-1953132 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin