Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2460107..2460630 Replicon chromosome
Accession NZ_CP102974
Organism Staphylococcus aureus strain 01-RR-86

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NW945_RS12110 Protein ID WP_258414328.1
Coordinates 2460107..2460373 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag NW945_RS12115 Protein ID WP_000587619.1
Coordinates 2460373..2460630 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW945_RS12090 (NW945_12090) 2455415..2456602 - 1188 WP_000026187.1 MFS transporter -
NW945_RS12095 (NW945_12095) 2456998..2457774 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW945_RS12100 (NW945_12100) 2457767..2458429 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
NW945_RS12105 (NW945_12105) 2458677..2459753 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW945_RS12110 (NW945_12110) 2460107..2460373 - 267 WP_258414328.1 Txe/YoeB family addiction module toxin Toxin
NW945_RS12115 (NW945_12115) 2460373..2460630 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW945_RS12120 (NW945_12120) 2460990..2461445 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NW945_RS12125 (NW945_12125) 2461612..2463189 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
NW945_RS12130 (NW945_12130) 2463384..2464133 + 750 WP_258414329.1 CPBP family lipoprotein N-acylation protein LnsB -
NW945_RS12135 (NW945_12135) 2464357..2465550 - 1194 WP_258414330.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10672.30 Da        Isoelectric Point: 10.1384

>T254766 WP_258414328.1 NZ_CP102974:c2460373-2460107 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT254766 WP_000587619.1 NZ_CP102974:c2460630-2460373 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References