Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2403382..2403899 Replicon chromosome
Accession NZ_CP102974
Organism Staphylococcus aureus strain 01-RR-86

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW945_RS11835 Protein ID WP_000113262.1
Coordinates 2403382..2403648 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW945_RS11840 Protein ID WP_000584499.1
Coordinates 2403648..2403899 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW945_RS11805 (NW945_11805) 2398801..2399337 - 537 WP_258414313.1 GNAT family N-acetyltransferase -
NW945_RS11810 (NW945_11810) 2399571..2400395 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW945_RS11815 (NW945_11815) 2400612..2400794 - 183 WP_000079140.1 hypothetical protein -
NW945_RS11820 (NW945_11820) 2400881..2401348 - 468 WP_258414315.1 SRPBCC domain-containing protein -
NW945_RS11825 (NW945_11825) 2401534..2403087 - 1554 WP_258414316.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW945_RS11830 (NW945_11830) 2403276..2403347 - 72 Protein_2282 hypothetical protein -
NW945_RS11835 (NW945_11835) 2403382..2403648 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW945_RS11840 (NW945_11840) 2403648..2403899 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW945_RS11845 (NW945_11845) 2404064..2404144 - 81 WP_223197974.1 hypothetical protein -
NW945_RS11850 (NW945_11850) 2404172..2404771 - 600 WP_000162810.1 DsbA family protein -
NW945_RS11855 (NW945_11855) 2404790..2405152 - 363 WP_258410229.1 DUF4467 domain-containing protein -
NW945_RS11860 (NW945_11860) 2405407..2406657 + 1251 WP_258414317.1 FemA/FemB family glycyltransferase FmhA -
NW945_RS11865 (NW945_11865) 2406742..2407473 - 732 WP_258413133.1 amino acid ABC transporter ATP-binding protein -
NW945_RS11870 (NW945_11870) 2407470..2408189 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254764 WP_000113262.1 NZ_CP102974:c2403648-2403382 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254764 WP_000584499.1 NZ_CP102974:c2403899-2403648 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References