254756

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2537742..2538265 Replicon chromosome
Accession NZ_CP102972
Organism Staphylococcus aureus strain 05-RR-90

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag NW963_RS12705 Protein ID WP_000074043.1
Coordinates 2537742..2538008 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag NW963_RS12710 Protein ID WP_000587618.1
Coordinates 2538008..2538265 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW963_RS12685 (NW963_12680) 2533048..2534235 - 1188 WP_000026187.1 MFS transporter -
NW963_RS12690 (NW963_12685) 2534631..2535407 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW963_RS12695 (NW963_12690) 2535400..2536062 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
NW963_RS12700 (NW963_12695) 2536310..2537386 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW963_RS12705 (NW963_12700) 2537742..2538008 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
NW963_RS12710 (NW963_12705) 2538008..2538265 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW963_RS12715 (NW963_12710) 2538624..2539079 + 456 WP_000732091.1 DUF1307 domain-containing protein -
NW963_RS12720 (NW963_12715) 2539247..2540824 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
NW963_RS12725 (NW963_12720) 2541020..2541769 + 750 WP_000072465.1 CPBP family lipoprotein N-acylation protein LnsB -
NW963_RS12730 (NW963_12725) 2541993..2543186 - 1194 WP_258412330.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T254756 WP_000074043.1 NZ_CP102972:c2538008-2537742 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT254756 WP_000587618.1 NZ_CP102972:c2538265-2538008 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB T1YCD0


Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References