Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2478901..2479418 Replicon chromosome
Accession NZ_CP102972
Organism Staphylococcus aureus strain 05-RR-90

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NW963_RS12425 Protein ID WP_258412323.1
Coordinates 2478901..2479167 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW963_RS12430 Protein ID WP_000584499.1
Coordinates 2479167..2479418 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW963_RS12395 (NW963_12390) 2474324..2474860 - 537 WP_070002486.1 GNAT family N-acetyltransferase -
NW963_RS12400 (NW963_12395) 2475094..2475918 - 825 WP_000594630.1 formate/nitrite transporter family protein -
NW963_RS12405 (NW963_12400) 2476134..2476319 - 186 WP_000230293.1 hypothetical protein -
NW963_RS12410 (NW963_12405) 2476403..2476870 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW963_RS12415 (NW963_12410) 2477056..2478606 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW963_RS12420 (NW963_12415) 2478795..2478866 - 72 Protein_2400 hypothetical protein -
NW963_RS12425 (NW963_12420) 2478901..2479167 - 267 WP_258412323.1 Txe/YoeB family addiction module toxin Toxin
NW963_RS12430 (NW963_12425) 2479167..2479418 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW963_RS12435 (NW963_12430) 2479583..2479663 - 81 WP_223197974.1 hypothetical protein -
NW963_RS12440 (NW963_12435) 2479691..2480290 - 600 WP_000162810.1 DsbA family protein -
NW963_RS12445 (NW963_12440) 2480309..2480671 - 363 WP_258412324.1 DUF4467 domain-containing protein -
NW963_RS12450 (NW963_12445) 2480926..2482176 + 1251 WP_258412325.1 FemA/FemB family glycyltransferase FmhA -
NW963_RS12455 (NW963_12450) 2482273..2483004 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW963_RS12460 (NW963_12455) 2483001..2483720 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10423.88 Da        Isoelectric Point: 9.7634

>T254754 WP_258412323.1 NZ_CP102972:c2479167-2478901 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGNPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254754 WP_000584499.1 NZ_CP102972:c2479418-2479167 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References