Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2400560..2401077 Replicon chromosome
Accession NZ_CP102971
Organism Staphylococcus aureus strain 08-G-E

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW975_RS11820 Protein ID WP_000113262.1
Coordinates 2400560..2400826 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW975_RS11825 Protein ID WP_000584499.1
Coordinates 2400826..2401077 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW975_RS11790 (NW975_11790) 2395985..2396521 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW975_RS11795 (NW975_11795) 2396755..2397579 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW975_RS11800 (NW975_11800) 2397796..2397978 - 183 WP_000079140.1 hypothetical protein -
NW975_RS11805 (NW975_11805) 2398065..2398532 - 468 WP_258410228.1 SRPBCC domain-containing protein -
NW975_RS11810 (NW975_11810) 2398718..2400265 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW975_RS11815 (NW975_11815) 2400454..2400525 - 72 Protein_2279 hypothetical protein -
NW975_RS11820 (NW975_11820) 2400560..2400826 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW975_RS11825 (NW975_11825) 2400826..2401077 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW975_RS11830 (NW975_11830) 2401242..2401322 - 81 WP_223197974.1 hypothetical protein -
NW975_RS11835 (NW975_11835) 2401350..2401949 - 600 WP_000162810.1 DsbA family protein -
NW975_RS11840 (NW975_11840) 2401968..2402330 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW975_RS11845 (NW975_11845) 2402585..2403835 + 1251 WP_258412659.1 FemA/FemB family glycyltransferase FmhA -
NW975_RS11850 (NW975_11850) 2403932..2404663 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW975_RS11855 (NW975_11855) 2404660..2405379 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254744 WP_000113262.1 NZ_CP102971:c2400826-2400560 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254744 WP_000584499.1 NZ_CP102971:c2401077-2400826 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References