Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2481127..2481311 Replicon chromosome
Accession NZ_CP102970
Organism Staphylococcus aureus strain 09-G-F

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag NW983_RS12335 Protein ID WP_000482647.1
Coordinates 2481204..2481311 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2481127..2481187 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW983_RS12325 (NW983_12325) 2476976..2478709 - 1734 WP_258411843.1 ABC transporter ATP-binding protein -
NW983_RS12330 (NW983_12330) 2478734..2480497 - 1764 WP_001064814.1 ABC transporter ATP-binding protein -
- 2481127..2481187 + 61 - - Antitoxin
NW983_RS12335 (NW983_12335) 2481204..2481311 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
NW983_RS12340 (NW983_12340) 2481446..2481832 - 387 WP_000779360.1 flippase GtxA -
NW983_RS12345 (NW983_12345) 2482090..2483232 + 1143 WP_216804653.1 glycerate kinase -
NW983_RS12350 (NW983_12350) 2483292..2483951 + 660 WP_000831298.1 membrane protein -
NW983_RS12355 (NW983_12355) 2484133..2485344 + 1212 WP_001192075.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgC / hlgB 2455066..2488625 33559
- flank IS/Tn - - 2475241..2476887 1646
- flank IS/Tn - - 2485643..2487289 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T254736 WP_000482647.1 NZ_CP102970:c2481311-2481204 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT254736 NZ_CP102970:2481127-2481187 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References