Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2451694..2452211 Replicon chromosome
Accession NZ_CP102970
Organism Staphylococcus aureus strain 09-G-F

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW983_RS12185 Protein ID WP_000113262.1
Coordinates 2451694..2451960 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW983_RS12190 Protein ID WP_000584499.1
Coordinates 2451960..2452211 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW983_RS12155 (NW983_12155) 2447118..2447654 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW983_RS12160 (NW983_12160) 2447887..2448711 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW983_RS12165 (NW983_12165) 2448928..2449110 - 183 WP_000230294.1 hypothetical protein -
NW983_RS12170 (NW983_12170) 2449194..2449661 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW983_RS12175 (NW983_12175) 2449847..2451400 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW983_RS12180 (NW983_12180) 2451588..2451659 - 72 WP_223200558.1 hypothetical protein -
NW983_RS12185 (NW983_12185) 2451694..2451960 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW983_RS12190 (NW983_12190) 2451960..2452211 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW983_RS12195 (NW983_12195) 2452376..2452477 - 102 WP_031867537.1 hypothetical protein -
NW983_RS12200 (NW983_12200) 2452484..2453083 - 600 WP_000162810.1 DsbA family protein -
NW983_RS12205 (NW983_12205) 2453102..2453464 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW983_RS12210 (NW983_12210) 2453719..2454969 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
NW983_RS12215 (NW983_12215) 2455066..2455797 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW983_RS12220 (NW983_12220) 2455794..2456513 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254735 WP_000113262.1 NZ_CP102970:c2451960-2451694 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254735 WP_000584499.1 NZ_CP102970:c2452211-2451960 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References