Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2401394..2401578 Replicon chromosome
Accession NZ_CP102968
Organism Staphylococcus aureus strain 13-G-52

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag NW965_RS11755 Protein ID WP_000482652.1
Coordinates 2401471..2401578 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2401394..2401454 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW965_RS11740 (NW965_11735) 2396849..2397016 - 168 WP_001789205.1 hypothetical protein -
NW965_RS11745 (NW965_11740) 2397247..2398980 - 1734 WP_049307645.1 ABC transporter ATP-binding protein -
NW965_RS11750 (NW965_11745) 2399005..2400768 - 1764 WP_001064837.1 ABC transporter ATP-binding protein -
- 2401394..2401454 + 61 - - Antitoxin
NW965_RS11755 (NW965_11750) 2401471..2401578 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
NW965_RS11760 (NW965_11755) 2401712..2402098 - 387 WP_000779357.1 flippase GtxA -
NW965_RS11765 (NW965_11760) 2402366..2403508 + 1143 WP_001176863.1 glycerate kinase -
NW965_RS11770 (NW965_11765) 2403568..2404227 + 660 WP_000831298.1 membrane protein -
NW965_RS11775 (NW965_11770) 2404409..2405620 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
NW965_RS11780 (NW965_11775) 2405743..2406216 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T254725 WP_000482652.1 NZ_CP102968:c2401578-2401471 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT254725 NZ_CP102968:2401394-2401454 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References