Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2375976..2376493 Replicon chromosome
Accession NZ_CP102968
Organism Staphylococcus aureus strain 13-G-52

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW965_RS11620 Protein ID WP_000113262.1
Coordinates 2375976..2376242 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW965_RS11625 Protein ID WP_000584499.1
Coordinates 2376242..2376493 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW965_RS11590 (NW965_11585) 2371393..2371929 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW965_RS11595 (NW965_11590) 2372162..2372986 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW965_RS11600 (NW965_11595) 2373203..2373385 - 183 WP_000230294.1 hypothetical protein -
NW965_RS11605 (NW965_11600) 2373469..2373936 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW965_RS11610 (NW965_11605) 2374122..2375681 - 1560 WP_162665619.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW965_RS11615 (NW965_11610) 2375870..2375941 - 72 Protein_2239 hypothetical protein -
NW965_RS11620 (NW965_11615) 2375976..2376242 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW965_RS11625 (NW965_11620) 2376242..2376493 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW965_RS11630 (NW965_11625) 2376658..2376738 - 81 WP_223197974.1 hypothetical protein -
NW965_RS11635 (NW965_11630) 2376766..2377365 - 600 WP_000162810.1 DsbA family protein -
NW965_RS11640 (NW965_11635) 2377384..2377746 - 363 WP_258410229.1 DUF4467 domain-containing protein -
NW965_RS11645 (NW965_11640) 2378001..2379251 + 1251 WP_258410230.1 FemA/FemB family glycyltransferase FmhA -
NW965_RS11650 (NW965_11645) 2379336..2380067 - 732 WP_258413133.1 amino acid ABC transporter ATP-binding protein -
NW965_RS11655 (NW965_11650) 2380064..2380783 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254724 WP_000113262.1 NZ_CP102968:c2376242-2375976 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254724 WP_000584499.1 NZ_CP102968:c2376493-2376242 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References