Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2454731..2455254 Replicon chromosome
Accession NZ_CP102967
Organism Staphylococcus aureus strain 17-H-61

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag NW947_RS12140 Protein ID WP_000074045.1
Coordinates 2454731..2454997 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag NW947_RS12145 Protein ID WP_000587619.1
Coordinates 2454997..2455254 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW947_RS12120 (NW947_12120) 2450037..2451224 - 1188 WP_000026194.1 MFS transporter -
NW947_RS12125 (NW947_12125) 2451620..2452396 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW947_RS12130 (NW947_12130) 2452389..2453051 - 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
NW947_RS12135 (NW947_12135) 2453299..2454375 - 1077 WP_001076671.1 M42 family metallopeptidase -
NW947_RS12140 (NW947_12140) 2454731..2454997 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
NW947_RS12145 (NW947_12145) 2454997..2455254 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW947_RS12150 (NW947_12150) 2455614..2456069 + 456 WP_258416349.1 YehR family lipoprotein -
NW947_RS12155 (NW947_12155) 2456237..2457814 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
NW947_RS12160 (NW947_12160) 2458009..2458758 + 750 WP_258416351.1 CPBP family lipoprotein N-acylation protein LnsB -
NW947_RS12165 (NW947_12165) 2458989..2460182 - 1194 WP_258416352.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T254717 WP_000074045.1 NZ_CP102967:c2454997-2454731 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT254717 WP_000587619.1 NZ_CP102967:c2455254-2454997 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References