Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2423188..2423372 Replicon chromosome
Accession NZ_CP102967
Organism Staphylococcus aureus strain 17-H-61

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag NW947_RS12000 Protein ID WP_000482652.1
Coordinates 2423265..2423372 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2423188..2423248 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW947_RS11985 (NW947_11985) 2418643..2418810 - 168 WP_250755633.1 hypothetical protein -
NW947_RS11990 (NW947_11990) 2419041..2420774 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
NW947_RS11995 (NW947_11995) 2420799..2422562 - 1764 WP_258416336.1 ABC transporter ATP-binding protein -
- 2423188..2423248 + 61 - - Antitoxin
NW947_RS12000 (NW947_12000) 2423265..2423372 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
NW947_RS12005 (NW947_12005) 2423506..2423892 - 387 WP_000779360.1 flippase GtxA -
NW947_RS12010 (NW947_12010) 2424150..2425292 + 1143 WP_001176863.1 glycerate kinase -
NW947_RS12015 (NW947_12015) 2425352..2426005 + 654 WP_053012342.1 hypothetical protein -
NW947_RS12020 (NW947_12020) 2426187..2427398 + 1212 WP_001191923.1 multidrug effflux MFS transporter -
NW947_RS12025 (NW947_12025) 2427521..2427994 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T254716 WP_000482652.1 NZ_CP102967:c2423372-2423265 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT254716 NZ_CP102967:2423188-2423248 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References