Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2397881..2398398 Replicon chromosome
Accession NZ_CP102967
Organism Staphylococcus aureus strain 17-H-61

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW947_RS11865 Protein ID WP_000113262.1
Coordinates 2397881..2398147 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW947_RS11870 Protein ID WP_000584499.1
Coordinates 2398147..2398398 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW947_RS11835 (NW947_11835) 2393306..2393842 - 537 WP_258416331.1 GNAT family N-acetyltransferase -
NW947_RS11840 (NW947_11840) 2394076..2394900 - 825 WP_064136627.1 formate/nitrite transporter family protein -
NW947_RS11845 (NW947_11845) 2395117..2395299 - 183 WP_000230294.1 hypothetical protein -
NW947_RS11850 (NW947_11850) 2395383..2395850 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW947_RS11855 (NW947_11855) 2396036..2397586 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW947_RS11860 (NW947_11860) 2397775..2397846 - 72 Protein_2289 hypothetical protein -
NW947_RS11865 (NW947_11865) 2397881..2398147 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW947_RS11870 (NW947_11870) 2398147..2398398 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW947_RS11875 (NW947_11875) 2398563..2398643 - 81 WP_232329130.1 hypothetical protein -
NW947_RS11880 (NW947_11880) 2398671..2399270 - 600 WP_000162810.1 DsbA family protein -
NW947_RS11885 (NW947_11885) 2399289..2399651 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW947_RS11890 (NW947_11890) 2399906..2401156 + 1251 WP_044291015.1 FemA/FemB family glycyltransferase FmhA -
NW947_RS11895 (NW947_11895) 2401253..2401984 - 732 WP_086037369.1 amino acid ABC transporter ATP-binding protein -
NW947_RS11900 (NW947_11900) 2401981..2402700 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254715 WP_000113262.1 NZ_CP102967:c2398147-2397881 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254715 WP_000584499.1 NZ_CP102967:c2398398-2398147 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References