Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2442455..2442639 Replicon chromosome
Accession NZ_CP102966
Organism Staphylococcus aureus strain 29-P-01

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag NW955_RS12100 Protein ID WP_000482652.1
Coordinates 2442532..2442639 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2442455..2442515 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW955_RS12085 (NW955_12085) 2437910..2438077 - 168 WP_001789205.1 hypothetical protein -
NW955_RS12090 (NW955_12090) 2438308..2440041 - 1734 WP_049307645.1 ABC transporter ATP-binding protein -
NW955_RS12095 (NW955_12095) 2440066..2441829 - 1764 WP_001064837.1 ABC transporter ATP-binding protein -
- 2442455..2442515 + 61 - - Antitoxin
NW955_RS12100 (NW955_12100) 2442532..2442639 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
NW955_RS12105 (NW955_12105) 2442773..2443159 - 387 WP_000779357.1 flippase GtxA -
NW955_RS12110 (NW955_12110) 2443427..2444569 + 1143 WP_001176863.1 glycerate kinase -
NW955_RS12115 (NW955_12115) 2444629..2445288 + 660 WP_000831298.1 membrane protein -
NW955_RS12120 (NW955_12120) 2445470..2446681 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
NW955_RS12125 (NW955_12125) 2446804..2447277 - 474 WP_258412664.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T254709 WP_000482652.1 NZ_CP102966:c2442639-2442532 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT254709 NZ_CP102966:2442455-2442515 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References