Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2417024..2417541 Replicon chromosome
Accession NZ_CP102966
Organism Staphylococcus aureus strain 29-P-01

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW955_RS11965 Protein ID WP_000113262.1
Coordinates 2417024..2417290 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW955_RS11970 Protein ID WP_000584499.1
Coordinates 2417290..2417541 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW955_RS11935 (NW955_11935) 2412449..2412985 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW955_RS11940 (NW955_11940) 2413219..2414043 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW955_RS11945 (NW955_11945) 2414260..2414442 - 183 WP_000079140.1 hypothetical protein -
NW955_RS11950 (NW955_11950) 2414529..2414996 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NW955_RS11955 (NW955_11955) 2415182..2416729 - 1548 WP_194382415.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW955_RS11960 (NW955_11960) 2416918..2416989 - 72 Protein_2308 hypothetical protein -
NW955_RS11965 (NW955_11965) 2417024..2417290 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW955_RS11970 (NW955_11970) 2417290..2417541 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW955_RS11975 (NW955_11975) 2417706..2417786 - 81 WP_223197974.1 hypothetical protein -
NW955_RS11980 (NW955_11980) 2417814..2418413 - 600 WP_000162810.1 DsbA family protein -
NW955_RS11985 (NW955_11985) 2418432..2418794 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW955_RS11990 (NW955_11990) 2419049..2420299 + 1251 WP_258412659.1 FemA/FemB family glycyltransferase FmhA -
NW955_RS11995 (NW955_11995) 2420396..2421127 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NW955_RS12000 (NW955_12000) 2421124..2421843 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254708 WP_000113262.1 NZ_CP102966:c2417290-2417024 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254708 WP_000584499.1 NZ_CP102966:c2417541-2417290 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References