Detailed information of TA system TA254701

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1108500..1109079
• Replicon: chromosome
• Accession: NZ_CP102966
• Organism: Staphylococcus aureus strain 29-P-01

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: NW955_RS05335
• Protein ID: WP_258411822.1
• Coordinates: 1108500..1108733 (+)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1108716..1109079 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW955_RS05295 (NW955_05295)	1104115..1105146	-	1032	WP_258412913.1	site-specific integrase	-
NW955_RS05300 (NW955_05300)	1105253..1105597	-	345	WP_258412914.1	DUF3969 family protein	-
NW955_RS05305 (NW955_05305)	1105597..1106079	-	483	WP_258412915.1	hypothetical protein	-
NW955_RS05310 (NW955_05310)	1106248..1106862	-	615	WP_258412916.1	hypothetical protein	-
NW955_RS05315 (NW955_05315)	1106887..1107348	-	462	WP_258412917.1	toxin	-
NW955_RS05320 (NW955_05320)	1107361..1107693	-	333	WP_258412918.1	helix-turn-helix transcriptional regulator	-
NW955_RS05325 (NW955_05325)	1107857..1108066	+	210	WP_196429541.1	helix-turn-helix transcriptional regulator	-
NW955_RS05330 (NW955_05330)	1108140..1108457	+	318	WP_196429542.1	hypothetical protein	-
NW955_RS05335 (NW955_05335)	1108500..1108733	+	234	WP_258411822.1	DUF2829 domain-containing protein	Toxin
-	1108716..1109079	-	364	-	-	Antitoxin
NW955_RS05345 (NW955_05345)	1109134..1109817	+	684	WP_258412920.1	BRO family protein	-
NW955_RS05350 (NW955_05350)	1109833..1110048	+	216	WP_258412921.1	DUF771 domain-containing protein	-
NW955_RS05355 (NW955_05355)	1110063..1110224	+	162	WP_258411818.1	DUF1270 domain-containing protein	-
NW955_RS05360 (NW955_05360)	1110319..1110621	+	303	WP_258412922.1	DUF2482 family protein	-
NW955_RS05365 (NW955_05365)	1110626..1110886	+	261	WP_113555199.1	DUF1108 family protein	-
NW955_RS05370 (NW955_05370)	1110895..1111158	+	264	WP_001205732.1	hypothetical protein	-
NW955_RS05375 (NW955_05375)	1111167..1113110	+	1944	WP_258412923.1	AAA family ATPase	-
NW955_RS05380 (NW955_05380)	1113112..1114032	+	921	WP_258412924.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hly/hla	1089006..1144549	55543

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8909.10 Da
• Isoelectric Point: 5.7783

>T254701 WP_258411822.1 NZ_CP102966:1108500-1108733 [Staphylococcus aureus]
MNIQEATKLATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISSSDGKSLVRYWQPSADDLMANDWEVVNPIRDQEL

Nucleotide

• Length: 234 bp

Antitoxin

Nucleotide

• Length: 364 bp

>AT254701 NZ_CP102966:c1109079-1108716 [Staphylococcus aureus]
ATGCCCTTGATATCCGATGAATTTGAGACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAATCAGGTTCTGTTAAATTAAGTTGTAATAATTTCGATGATGCTGAAGGTATACATTTAAAGTATTTTC
AAAAGTTGCATTTCGAAGATGTCGACAATGATTTAAAAAAACTTAAAAACTCCGGATTCCTCCATGGTGTGCTTGCAGAC
AACACTATTTATCATGTGACAATATCGGATAAGACTATTGTTTATTTCGAAAATAAGTTTAAAAACAATTTAAAAAGTAT
AATTGATAGTATTTCTAGTATTGCTTCTATAATTCCTGGTCTCT

Structures

Antitoxin