Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2501134..2501318 Replicon chromosome
Accession NZ_CP102963
Organism Staphylococcus aureus strain 40-B-50

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag NW941_RS12540 Protein ID WP_000482652.1
Coordinates 2501211..2501318 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2501134..2501194 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW941_RS12525 (NW941_12560) 2496664..2496831 - 168 WP_031860495.1 hypothetical protein -
NW941_RS12530 (NW941_12565) 2497062..2498795 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
NW941_RS12535 (NW941_12570) 2498820..2500583 - 1764 WP_064136629.1 ABC transporter ATP-binding protein -
- 2501134..2501194 + 61 - - Antitoxin
NW941_RS12540 (NW941_12575) 2501211..2501318 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
NW941_RS12545 (NW941_12580) 2501452..2501838 - 387 WP_000779358.1 flippase GtxA -
NW941_RS12550 (NW941_12585) 2502106..2503248 + 1143 WP_001176863.1 glycerate kinase -
NW941_RS12555 (NW941_12590) 2503308..2503967 + 660 WP_000831298.1 membrane protein -
NW941_RS12560 (NW941_12595) 2504149..2505360 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
NW941_RS12565 (NW941_12600) 2505483..2505956 - 474 WP_043044951.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T254698 WP_000482652.1 NZ_CP102963:c2501318-2501211 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT254698 NZ_CP102963:2501134-2501194 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References