Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2475778..2476295 Replicon chromosome
Accession NZ_CP102963
Organism Staphylococcus aureus strain 40-B-50

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NW941_RS12405 Protein ID WP_000113262.1
Coordinates 2475778..2476044 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW941_RS12410 Protein ID WP_000584499.1
Coordinates 2476044..2476295 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW941_RS12375 (NW941_12410) 2471203..2471739 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NW941_RS12380 (NW941_12415) 2471973..2472797 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NW941_RS12385 (NW941_12420) 2473014..2473196 - 183 WP_000079140.1 hypothetical protein -
NW941_RS12390 (NW941_12425) 2473283..2473750 - 468 WP_258410228.1 SRPBCC domain-containing protein -
NW941_RS12395 (NW941_12430) 2473936..2475483 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW941_RS12400 (NW941_12435) 2475672..2475743 - 72 Protein_2396 hypothetical protein -
NW941_RS12405 (NW941_12440) 2475778..2476044 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NW941_RS12410 (NW941_12445) 2476044..2476295 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW941_RS12415 (NW941_12450) 2476460..2476540 - 81 WP_223197974.1 hypothetical protein -
NW941_RS12420 (NW941_12455) 2476568..2477167 - 600 WP_000162810.1 DsbA family protein -
NW941_RS12425 (NW941_12460) 2477186..2477548 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NW941_RS12430 (NW941_12465) 2477803..2479053 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
NW941_RS12435 (NW941_12470) 2479150..2479881 - 732 WP_072497482.1 amino acid ABC transporter ATP-binding protein -
NW941_RS12440 (NW941_12475) 2479878..2480597 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T254697 WP_000113262.1 NZ_CP102963:c2476044-2475778 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254697 WP_000584499.1 NZ_CP102963:c2476295-2476044 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References