Detailed information of TA system TA254695

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2351931..2352510
• Replicon: chromosome
• Accession: NZ_CP102963
• Organism: Staphylococcus aureus strain 40-B-50

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: NW941_RS11800
• Protein ID: WP_258411822.1
• Coordinates: 2352277..2352510 (-)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2351931..2352294 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW941_RS11760 (NW941_11795)	2347786..2349729	-	1944	WP_258415083.1	AAA family ATPase	-
NW941_RS11765 (NW941_11800)	2349738..2350001	-	264	WP_001205732.1	hypothetical protein	-
NW941_RS11770 (NW941_11805)	2350010..2350270	-	261	WP_258411816.1	DUF1108 family protein	-
NW941_RS11775 (NW941_11810)	2350275..2350577	-	303	WP_258411817.1	DUF2482 family protein	-
NW941_RS11780 (NW941_11815)	2350669..2350830	-	162	WP_258411818.1	DUF1270 domain-containing protein	-
NW941_RS11785 (NW941_11820)	2350843..2351106	-	264	WP_258411819.1	helix-turn-helix domain-containing protein	-
NW941_RS11790 (NW941_11825)	2351121..2351876	-	756	WP_258411820.1	phage regulatory protein/antirepressor Ant	-
-	2351931..2352294	+	364	-	-	Antitoxin
NW941_RS11800 (NW941_11835)	2352277..2352510	-	234	WP_258411822.1	DUF2829 domain-containing protein	Toxin
NW941_RS11805 (NW941_11840)	2352553..2352870	-	318	WP_258411823.1	hypothetical protein	-
NW941_RS11810 (NW941_11845)	2352886..2353095	-	210	WP_047447803.1	helix-turn-helix transcriptional regulator	-
NW941_RS11815 (NW941_11850)	2353292..2353921	+	630	WP_258411824.1	XRE family transcriptional regulator	-
NW941_RS11820 (NW941_11855)	2353936..2354520	+	585	WP_258415084.1	3'-5' exonuclease	-
NW941_RS11825 (NW941_11860)	2354541..2354825	+	285	WP_258415085.1	BRCT domain-containing protein	-
NW941_RS11830 (NW941_11865)	2354856..2355002	+	147	WP_078064955.1	hypothetical protein	-
NW941_RS11835 (NW941_11870)	2354999..2355613	-	615	WP_258414930.1	ATPase	-
NW941_RS11840 (NW941_11875)	2355739..2356944	+	1206	WP_258415086.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2315869..2370990	55121

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8909.10 Da
• Isoelectric Point: 5.7783

>T254695 WP_258411822.1 NZ_CP102963:c2352510-2352277 [Staphylococcus aureus]
MNIQEATKLATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISSSDGKSLVRYWQPSADDLMANDWEVVNPIRDQEL

Nucleotide

• Length: 234 bp

Antitoxin

Nucleotide

• Length: 364 bp

>AT254695 NZ_CP102963:2351931-2352294 [Staphylococcus aureus]
ATGCCCTTGATATCCGATGAATTTGAGACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAATCAGGTTCTGTTAAATTAAGTTGTAATAATTTCGATGATGCTGAAGGTATACATTTAAAGTATTTTC
AAAAGTTGCATTTCGAAGATGTCGACAATGATTTAAAAAAACTTAAAAACTCCGGATTCCTCCATGGTGTGCTTGCAGAC
AACACTATTTATCATGTGACAATATCGGATAAGACTATTGTTTATTTCGAAAATAAGTTTAAAAACAATTTAAAAAGTAT
AATTGATAGTATTTCTAGTATTGCTTCTATAATTCCTGGTCTCT

Structures

Antitoxin