Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2487844..2488361 Replicon chromosome
Accession NZ_CP102962
Organism Staphylococcus aureus strain 16CS0212

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag NW971_RS12480 Protein ID WP_000113263.1
Coordinates 2487844..2488110 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NW971_RS12485 Protein ID WP_000584499.1
Coordinates 2488110..2488361 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW971_RS12450 (NW971_12450) 2482935..2483471 - 537 WP_111762830.1 GNAT family N-acetyltransferase -
NW971_RS12455 (NW971_12455) 2484053..2484877 - 825 WP_000594633.1 formate/nitrite transporter family protein -
NW971_RS12460 (NW971_12460) 2485081..2485263 - 183 WP_258464482.1 hypothetical protein -
NW971_RS12465 (NW971_12465) 2485350..2485817 - 468 WP_258464483.1 SRPBCC domain-containing protein -
NW971_RS12470 (NW971_12470) 2486003..2487550 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NW971_RS12475 (NW971_12475) 2487729..2487809 - 81 WP_225539491.1 hypothetical protein -
NW971_RS12480 (NW971_12480) 2487844..2488110 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
NW971_RS12485 (NW971_12485) 2488110..2488361 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW971_RS12490 (NW971_12490) 2488627..2489226 - 600 WP_000162810.1 DsbA family protein -
NW971_RS12495 (NW971_12495) 2489245..2489607 - 363 WP_000819844.1 DUF4467 domain-containing protein -
NW971_RS12500 (NW971_12500) 2489862..2491112 + 1251 WP_148843647.1 FemA/FemB family glycyltransferase FmhA -
NW971_RS12505 (NW971_12505) 2491209..2491940 - 732 WP_000615462.1 amino acid ABC transporter ATP-binding protein -
NW971_RS12510 (NW971_12510) 2491937..2492656 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T254686 WP_000113263.1 NZ_CP102962:c2488110-2487844 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT254686 WP_000584499.1 NZ_CP102962:c2488361-2488110 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References